He said two additional victims were also injured in the shooting and were receiving medical care.
"This is a message any leader hopes never to have to send, and I am devastated that this violence has visited the University of Virginia," Ryan said.
"Call 911 if seen, do not approach," the University of Virginia Police Department warned in a tweet, sharing a photo of Jones.
The suspect was last seen wearing a burgundy jacket, blue jeans and red shoes, the university's emergency management office said, adding that he could be driving a black SUV.
In a later update shared at around 2:55 a.m. EST, the university's emergency management office said multiple agencies, including a Virginia State Police helicopter, were still searching for the suspect.